‘Patients will suffer’: tales from the frontline of the UK pharma crisis

The pricing standoff between government and industry has stalled research and put thousands of jobs at risk

Microsoft reports strong earnings as Azure hit by major outage

Tech giant reports earnings of $3.72 per share day after deal with OpenAI pushed value of company to more than $4tn

Telegraph sale in turmoil after lead bidder linked to China’s politburo

Media group’s own paper publishes photograph of RedBird Capital chair with alleged spy ring chief

Meta reports mixed financial results amid spree of AI hiring and spending

Tech company brings in record quarterly revenue but major tax bill dampens earnings per share

Google parent Alphabet beats forecasts with first $100bn quarter

Strong demand for ads and cloud services powered tech giant’s growth as it makes multibillion-dollar AI investment

Pound sinks against euro and dollar as tax rises loom and growth slows

Prospect of a tough budget is thought to have brought forward the likely date for a cut in interest rates to 3.75%

Fed cuts interest rates for second time this year amid economic uncertainty

Central bank sets rates at range between 3.75% and 4% amid turbulence from government shutdown and Trump’s tariffs

CBS News staffers lose jobs in ‘bloodbath’ as part of sweeping cuts from Paramount

Paramount laying off about 1,000 staffers, including some in news, on Wednesday amid longer-term cost-cutting plan

The Guardian view on Argentina’s election: one step closer to becoming a Trumpian client state

Editorial: A $40bn rescue may have helped Javier Milei scrape through midterms, but it leaves Argentina’s democracy and economy more dependent than ever on Washington

EU carmakers ‘days away’ from halting work as chip war with China escalates

Industry body says reserves of Nexperia semiconductors are dwindling after Beijing bans exports of key components

‘Cable Cowboy’ John Malone to step down from his media empire

Retirement of billionaire, 84, leaves Rupert Murdoch as last of that generation to be actively involved in media business

Nvidia becomes world’s first $5tn company amid stock market and AI boom

Silicon Valley chipmaker hits $5tn valuation just three months after it was first to break through the $4tn barrier

Wall Street hits new highs as Nvidia becomes world’s first $5tn company – as it happened

Donald Trump says he will cut fentanyl tariff on Chinese goods and expects ‘great deal’ with Xi Jinping

UK must reform drug pricing to become life sciences superpower, says GSK boss

Shares jump on higher profits as Emma Walmsley is ‘hopeful’ standoff with NHS can be resolved

The UK bond markets have become a political trap that strangles public spending. But there’s a way out

With living standards falling and the far right on the rise, the chancellor has the power to make decisions, not simply accept diktats from the markets, says lecturer in political economy Sahil Dutta