Peter Mandelson’s advisory firm cuts ties amid Jeffrey Epstein revelations

Global Counsel, co-founded by the sacked ambassador to the US, is selling off his multimillion-pound stake

UK imposes 100 new sanctions targeting Russia’s revenues and military supplies

Electronics firms and ‘shadow fleet’ carrying oil among targets as UK foreign secretary, Yvette Cooper, travels to Ukraine

Business rates rise would put hundreds of big shops at risk, say UK retailers

Concern for ‘anchor tenants’ as trade body warns that stores could put up prices or cut jobs to protect profits

UK must heed Sir John Bell’s big pharma investment warning

Instead of making silly statements the government needs to look at why Merck has scrapped its £1bn research centre

Green energy entrepreneur calls on UK to subsidise North Sea oil and gas firms

Dale Vince urges ministers to ‘optimise’ resources in fossil fuel basin to help smooth transition to renewables

A banya with a billionaire, an undeclared loan and ‘pure poison’: the many scandals of Peter Mandelson

Despite his value to Starmer, the New Labour veteran has been forced into an extraordinary third resignation

Big pharma will stop investing in UK, top scientist warns after Merck’s £1bn exit

Comments by former professor of medicine at Oxford follow scrapping of planned London research centre

Let France be a warning, Rachel Reeves: stand up to the bond market vigilantes, or they’ll come for Britain next

Labour can stick with ‘you can’t buck the markets’ – or challenge the economic orthodoxy that has served narrow class interests for 50 years, says Guardian columnist Larry Elliott

Pre-budget howls from big business beasts go deeper than the usual tax grumbles

Top executives say ministers don’t ‘get’ business, they aren’t listening and key decisions are fluffed or take too long

US drugmaker Merck scraps £1bn London research centre and cuts 125 science jobs

New blow to UK’s key life science sector as industry body says country is losing ground on investment and research

Rachel Reeves tells private equity bosses she plans to shut down more regulators

Chancellor stopped short of saying which regulators were in government’s crosshairs

Starmer tightens grip on economic policy by strengthening autumn ‘budget board’

Key figures from No 10 and No 11 appointed to group include Torsten Bell, new economic adviser Minouche Shafik and comms chief Tim Allan

CBI boss calls for Reeves to tear up Labour’s pledge not to raise tax

Rain Newton-Smith tells chancellor ‘the time for tinkering is over’ and revisit promise not to raise taxes on working people

Peter Kyle, the ‘tech bro’ minister charged with kickstarting UK growth

‘Hard-working’ business secretary opens his tenure with delicate trade missions to Washington and Beijing

Reform UK would axe any high-speed northern rail schemes, says Richard Tice

Deputy leader tells firms considering bidding for contracts to ‘not bother’ as party would spend on what ‘country needs more’