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Novo Nordisk shares slide after Ozempic pill fails in Alzheimer’s trials

Report dashes hopes for new use for blockbuster weight-loss drug

EU and US to restart trade talks as sticking points on July tariff deal remain

US officials to hold high-level talks in Brussels amid unhappiness in Washington at slow action on July deal

‘The French people want to save us’: help pours in for glassmaker Duralex

The brand, which evokes nostalgia and pride, hit its €5m fundraising target within hours and orders have soared

Europe’s economy is geared towards a disappearing world, says ECB’s Lagarde

Central bank chief warns that the bloc’s dependence on third countries for trade and security has left it vulnerable

Wetherspoons to open first pub in Spain – offering garlic prawns and beer from 6am

Opening in Alicante airport is the chain’s first move into mainland Europe, and will offer outdoor drinking

Onboard the world’s largest sailing cargo ship: is this the future of travel and transport?

The Neoliner Origin set off on its inaugural two-week voyage from France to the US with the aim of revolutionising the notoriously dirty shipping industry

Visma approaches City grandee to act as chair if €20bn London listing goes ahead

Norwegian software group looks to ex-Worldpay boss Sir Ron Kalifa as it weighs up blockbuster flotation in London or Stockholm

TotalEnergies buys €5.1bn stake in Czech tycoon’s power plants business

Daniel Křetínský to become a major shareholder in French oil firm as part of deal creating 50/50 joint venture

Roman Abramovich makes claim of ‘conspiracy’ against Jersey government

Move threatens to throw open parts of secretive legal battle on Channel island about ex-Chelsea owner’s wealth

Global markets struggle after tech sell-off and fears over Chinese economy

Reaction follows Wall Street’s worst day in a month and unprecedented slump in investment in China

Trump accused of caving to big business after deal to cut Swiss tariffs to 15%

Rolex denies ‘any negotiation’ with US although luxury watchmaker entertained Trump and gave him gold clock

China voices ‘extreme disappointment’ with Dutch minister at centre of car chip row

Vincent Karremans called semiconductor supply chain crisis a ‘wake-up call for western leaders’

EU court rules non-alcoholic drinks cannot be called gin

Judges in Luxembourg say EU law prohibits use of term ‘non-alcoholic gin’, in case brought by German lobby group

Ineos to cut hundreds of jobs as carmaker struggles with debts

Company owned by billionaire Jim Ratcliffe says it is simplifying its head office to improve efficiency

EU investigates Google over ‘demotion’ of commercial content from news media

Some content created with advertisers is no longer visible, which could mean loss of revenue, officials say

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  • Wall Street hits six-month low as Trump ‘appears to lose his grip on markets’ – business live
  • UK government borrowing costs hit 5% as Iran war fuels bond market sell-off
  • Asda warns of ‘temporary shortages’ at some petrol pumps amid Iran war
  • Italy investigates beauty brands over concerns about young girls’ mental health
  • Ministers should ‘start doing stuff’ to help farmers and cut fuel costs, says Asda boss
  • ‘It’s fired people up’: support grows, including within Labor, for new gas tax to curb wartime profits
  • Blink and miss: Trump’s tactic of threats first and U-turn later is proving stale in Iran war
  • Brendan Carr: is Trump’s FCC chair uniquely powerful or a paper tiger?
  • UK car production falls 17% as industry warns of ‘worrying’ decline
  • Almost half a million Lloyds customers had personal data exposed in IT glitch
  • $30 an hour by 2030: new pushes to increase minimum wage in New York and California
  • Five firms including Autotrader and Just Eat investigated over fake review failings
  • I was paid to write fake Google reviews – then my ‘bosses’ tried to scam me
  • Governments controlling prices? It has long been unthinkable – but may now be inevitable
  • Trump signature to appear on US currency in first for sitting president
  • US markets see biggest slump since start of US-Israel war on Iran
  • The Guardian view on China and Iran: the war poses bigger questions for Beijing than where to get its oil
  • NS&I boss forced out as bank faces £470m payout over missing savings
  • The Middle East price shock hasn’t hit Next – yet
  • ‘Tehran’s tollbooth’: a visual guide to how a trickle of ships still passes through strait of Hormuz
  • NS&I chief executive replaced in ‘fresh start’ over missing savings crisis; bad day for markets – as it happened
  • War in Iran ‘not a Nato matter’, Finland president says in defence of alliance – as it happened
  • Next says Middle East conflict could raise clothing prices by up to 10%
  • Two salon owners wanted to go zero-waste. Could they do it and keep their business afloat?
  • Ministers vow to spend record £8.4bn on road maintenance in England
  • Starmer tells Travelodge boss to engage with MPs over sexual assault case
  • Octopus reports sharp rise in solar panel sales since start of Iran war
  • Sewage released into England’s rivers and seas nearly 300,000 times last year
  • Ticketmaster quietly raised other fees after US crackdown on hidden charges
  • Co-op boss quits after year marked by cyber-attack and claims of ‘toxic’ culture

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