Eli Lilly has put pressure on Britain to agree regular increases in NHS drug prices, in return for the US pharmaceutical company resuming investment in the UK.

Patrik Jonsson, president of Lilly’s international businesses, told the Financial Times the company was in talks with UK ministers and was feeling “optimistic” about hammering out an agreement by the summer, under which Britain would pay more for its medicines.

The talks will also explore “innovative” pricing plans linking payments for anti-obesity medication to whether patients become well enough to return to work as a result of their treatment, he said.

Lilly makes the bestselling weekly jabs Mounjaro and Zepbound for diabetes and weight loss respectively, and is gearing up for the launch of an anti-obesity pill.

Last September, Lilly said its planned London Gateway Lab, part of a £279m investment, was on hold, “as we are awaiting more clarity around the UK life sciences environment”.

The move came in the same week when US company Merck (also known as MSD) ditched its under-construction £1bn research centre in London and Britain’s biggest pharma firm AstraZeneca put a £200m investment in Cambridge on hold. Just before, talks between the industry and government about a rebate scheme collapsed.

Jonsson said to resume its investment, Lilly wants to see more action from the UK government – beyond the UK-US pricing deal announced in December.

What we would need to see is actually those goals turning into really a well-defined action plan with interventions and timelines.

Under pressure from Donald Trump who has complained about high drug prices in the US and lower prices elsewhere, Keir Starmer in December agreed to the first increase in NHS cost-effectiveness thresholds in 27 years, in return for the US dropping threatened tariffs on UK drugmakers.

This raised the price the health service will pay for drugs that give a patient a year of good-quality life from £20,000-£30,000 to £25,000-£35,000.

Ministers from the Department of Health will this week overrule civil service concerns about value for money and push ahead with the increase. An announcement is expected on Tuesday, although the US could still make changes to the agreement.

The government has agreed as part of the deal to double the UK’s spending on all drugs by 2035 from 0.3% to 0.6% of GDP.

Lilly wants the government to phase out its multibillion-pound rebate scheme, under which companies pay back a chunk of their revenues to the NHS. Jonsson said that prices for medicines in the UK had been

far too low for far too long, and even with the current threshold, we are not back to where we started more than 20 years ago. The threshold can’t be written in stone for another three decades.

Brent crude is on course for a record monthly rise of nearly 60%, exceeding gains it made during the 1990 Gulf War.

The global oil benchmark is currently trading 3.5% higher at $116.051 a barrel – up 59% so far in March – while New York light crude rose 2% to $101.6 a barrel.

Yemen’s Houthi rebels launched their first attacks on Israel over the weekend and Israel reported a second attack today, as the US-Israeli war with Iran widened. More US troops have arrived in the Middle East while the Israeli military said today that is it attacking government infrastructure “throughout Tehran”.

Vandana Hari, founder of oil market analysts Vanda Insights, said:

The market has all but discounted the prospect of a negotiated end to the war, Trump’s claims of ongoing ‘direct and indirect’ talks with Iran notwithstanding, and is bracing for a sharp escalation in military hostilities, which is a bullish signal for crude, with huge uncertainties on the timing and nature of the outcome.

Natural gas prices have also gone up again, amid concerns that supplies will be further disrupted. Dutch month-ahead futures rose 1.6% to just over €55 a megawatt-hour.

British fashion retailer Debenhams has raised its 2027 profit forecast after beating forecasts for last year, as its turnaround strategy is paying off.

The shares rose more than 6% on the news. The well-known brand made a comeback last March after the online retailer Boohoo rebranded as Debenhams. It embarked on measures to cut costs and debt amid fierce competition from low-cost fast fashion rivals such as Shein and the resale app Vinted.

Debenhams, which owns brands including PrettyLittleThing, Oasis, Warehouse and Karen Millen, forecast annual adjusted core profit of £53m for the year to 28 February, ahead of its previous guidance, driven by a 76% jump in second-half profit. It expects 2027 profits to grow in double digits.

Dan Finley, the chief executive, said:

Our multi-year turnaround strategy continues at pace. Our pivot to the stock-lite, capital-lite, highly profitable marketplace is working.

The cost base has been reset, the warehouse consolidation completed, the tech re-platform delivered, the stock base rightsized, most of the onerous costs exited and the brand management teams strengthened. This is significant progress, ahead of our plan, but there is still more to be delivered and we now focus on growth.

The company said all its brands are trading profitably, on an adjusted core profit basis. It raised £40m from shareholders in February, more than its initial target of £35m, backed by the Boohoo founder, Mahmud Kamani. It came less than 18 months after the group raised £39m from shareholders as it battled to revive sales.

The retailer has been locked in a drawn-out tussle with its top investor Frassers Group, majority-owned by retail tycoon Mike Ashley, which unsuccessfully tried to block the rebranding and out Kamani from the board.

Wayne Brown, analyst at Panmure Liberum, said:

This is the third upgrade this year and FY26 EBITDA has now been upgraded 51% since the same time last year.

Net debt is not overly stretching and is predicted to fall organically before we even see the sale of non-core assets.

The transformation work done has been huge and the noise (and costs) associated with these is now all but over.

Some may say it is too early to call, but all the signals and green shoots of the new business model are now visible and when investors start to recognise this, the shares will rally very hard.

Government bonds around the world are set for the biggest monthly losses in more than a year, as investors worry about the impact of a prolonged war in the Middle East on inflation and economic growth.

Declines in bond prices have pushed their yields (or interest rates) higher, although they eased on Monday.

The two-year US Treasury yield is set for a monthly rise of around 50 basis points, the biggest increase since October 2024. Australia’s three-year yield is also 50bps ahead in March, the most in 17 months. Japan’s two-year government bond yield has risen 12.5bps this month.

Moh Siong Sim, a strategist at the Singapore bank OCBC, told Reuters:

Now that the reality is sort of sinking in that perhaps the oil price might stay high for a bit longer, given that it’s hard to see an end to the war anytime soon, the growth impact is starting to become more of a focus.

The buzzword here is stagflation. Initial focus was on inflation. Now the ‘stag’ bit is moving into the picture, and that’s perhaps explained why short-ended bond yields have come off.

Oil prices have surged above $100 a barrel since the US and Israel began attacking Iran on 28 February. This has raised fears of higher inflation, and led to a dramatic shift in interest rate expectations. The Bank of England is now expected to raise interest rates, rather than cutting them, at least twice this year, as is the European Central Bank.

The US Federal Reserve, which has been under pressure from Donald Trump to cut rates, is forecast to leave them on hold.

Good morning, and welcome to our rolling coverage of business, the financial markets and the world economy.

Asian stock markets have fallen while oil prices have climbed further, after Donald Trump said he wants to “take the oil” in Iran.

Brent crude, the global oil benchmark, has risen a further 2.2% to $115.01 a barrel, up $2.4.

Asian stock markets have declined, with the exception of the Shanghai and Singapore exchanges, which have edged slightly higher. Japan’s Nikkei tumbled 3% and Hong Kong’s Hang Seng lost 1.1%.

Donald Trump has said his “preference would be to take the oil” in Iran and that US forces could seize the regime’s export hub on Kharg Island, the Financial Times is reporting, as the US sends thousands of troops to the Middle East.

The US president compares the potential move to Venezuela, where the US intends to control the oil industry “indefinitely” following its ousting of president Nicolás Maduro in January.

Trump said in the interview with the FT on Sunday:

To be honest with you, my favourite thing is to take the oil in Iran, but some stupid people back in the US say: ‘why are you doing that?’ But they’re stupid people.

You can follow the latest news on the Middle East here:

Keir Starmer will convene executives from the energy industry, shipping, banking and insurance at No 10 Downing Street today to discuss emergency measures to contain the continuing crisis from Iran’s blockade of the strait of Hormuz.

The roundtable includes leaders from Shell, BP, British Gas parent Centrica and Norway’s Equinor, as well as the insurance giant Lloyd’s of London (the centre of global shipping insurance), banking groups HSBC and Goldman Sachs, and container shipping companies, Denmark’s Maersk and France’s CMA CGM.

No 10 said it is intended to be a constructive meeting about the perilous state of the strait of Hormuz, a key shipping route through which about a fifth of global oil and gas supplies pass, our deputy political editor Jessica Elgot reported. It is likely to inform short and long-term contingency planning amid threats from Iran that it intends to assert sovereignty over the strait, including potentially charging vessels for access once the chokepoint is eventually reopened.

Separately, Rachel Reeves, the UK chancellor, will warn G7 nations they must move faster on clean energy to insulate economies against global price shocks from oil and gas as she and the energy secretary Ed Miliband meet G7 finance and energy ministers today.

The Agenda

• 9.30am BST: Bank of England mortgage lending and consumer credit

• 10am BST: Eurozone economic sentiment and consumer confidence

• 1pm BST: Germany inflation for March (preliminary estimate)